DeLong's test indicated no significant differences in the predictive value of [TIMP-2]• [IGFBP7] between the cardiac surgery group and the stroke (P=0.20) and sepsis (P=0.21) groups.<h4>Conclusion</h4>The combined prediction model, which integrates urinary [TIMP-2]• [IGFBP7] concentrations and AKI risk factors, significantly enhances AKI prediction. The gene discussed is TIMP2; the disease is Sepsis.