VWF and von Willebrand disease (hereditary or acquired): In 2020, it was estimated that 16.5 per 100 000 people in the UK had VWD (type 1: 7.2 per 100 000 people; type 2: 2.5 per 100 000; type 3: 0.3 per 100 000; remaining patients ‘unclassified’ or ‘low von Willebrand factor’ [VWF]) according to the UK National Haemophilia Database (NHD) [2].