Among these, PSMA-positive tumor volume (PSMA-TV) may carry prognostic significance but has been poorly investigated in patients receiving radical-intent radiotherapy (RT).<h4>Methods</h4>Patients with biopsy-proven unfavorable intermediate-to-high-risk PCa staged as non-metastatic (T1-4 N0-1 M0) at [<sup>68</sup> Ga]PSMA-11 or [<sup>18</sup>F]PSMA-1007 PET/CT before definitive RT plus androgen deprivation therapy (ADT) at our Institution (2019-2024) were retrospectively recruited. Here, FOLH1 is linked to posterior cortical atrophy.