To date, no study has specifically investigated the effects of acromegaly in treatment-naïve patients and whether among pituitary adenomas GH-secreting tumors not inducing optic chiasm compression might induce damage of retinal nervous and vascular structures due to a direct effect of GH and IGF-I excess is yet to be fully elucidated. This evidence concerns the gene IGF1 and pituitary gland adenoma.