Despite the ubiquitous expression of TDP‐43, oligodendrocytes, in the context of TDP‐43 related ALS, remain largely understudied, despite pathological TDP‐43 aggregates being identified in these myelinating cells (Barton, Magnani, et al. 2021; Heo et al. 2022; Neumann et al. 2007). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.