Common to 97% of all ALS patients is the pathological accumulation of TDP‐43 protein, an essential DNA and RNA binding protein required for transcription, splicing, and processing of RNA, maintaining mRNA stability, and RNA metabolism through communicating bi‐directionally between the cytoplasm and nucleus (Ayala et al. 2006; Dong and Chen 2018; Tollervey et al. 2011). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.