Further, while the TDP‐43Q331K mouse exhibits TDP‐43 proteinopathy, this mouse lacks gross TDP‐43 aggregation and has no survival deficit, raising the question as to whether oligodendrocyte and myelin changes would be more abundant in a more severe TDP‐43 model of ALS. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.