Although in female mice long‐term exposure to high salt altered the expression of aquaporins relevant for aldosterone‐dependent and ‐independent water absorption,42, 43 male HSD mice presented with augmented Crip1 expression, whose plasma levels are strongly associated with increases in blood pressure and cardiac hypertrophy,68 as well as higher Sgk1 expression levels, which have been suggested as a risk factor for the development of mineralocorticoid‐dependent kidney injury independently of blood pressure.69 The gene discussed is CHST3; the disease is cardiac hypertrophy.