CFTR and cystic fibrosis: In 2010, Rowe and coworkers confirmed that quercetin dissolved in DMSO activates CFTR‐mediated anion transport in respiratory epithelia in  vitro and in  vivo and demonstrated that quercetin indeed does not produce detectable phosphorylation of the isolated CFTR R‐domain.[18] In detail, using CFBE41o‐ human CF bronchial epithelial cells (a cell line derived from a cystic fibrosis patient homozygous for the ΔF508 CFTR mutation) results showed that quercetin produced a small increase in cAMP relative to forskolin, despite potent stimulation of ion transport compared with cAMP agonist.