The thesis of this work is that aptly formulated citrus flavonoids hold sigificant potential for developing a multitarget treatment of cystic fibrosis combining in a single treatment antimicrobial, anti‐inflammatory, CFTR‐stimulating, and immunomodulatory properties, as required by a genetic disease eventually causing chronic lung inflammation and bacterial infection reinforcing each other. The gene discussed is CFTR; the disease is bacterial infectious disease.