Further supporting the need to reinvigorate research on citrus flavonoids to treat CF, indeed, recent molecular docking and molecular dynamics calculations clearly showed that quercetin binds to the mutated CFTR protein structure active sites (via hydrophobic bonds, hydrogen bonds, and electrostatic interactions), remaining bound to the target protein favorably and dynamically, thereby inhibiting the effect of mutated CFTR protein through improved trafficking and restoration of original function.[31]. The gene discussed is CFTR; the disease is cystic fibrosis.