A Randomized Controlled Trial conducted by Parmar et al. in 1985 sought to evaluate and compare the safety and efficacy of two treatments for advanced prostate carcinoma: a slow-release formulation of D-Trp-6 luteinizing hormone-releasing hormone (D-Trp-6-LHRH) microcapsules and orchiectomy. This evidence concerns the gene GNRH1 and prostate carcinoma.