Added to its ability to induce T-cell apoptosis at high concentrations, lower concentrations of Gal-1 induce IL-10 secretion from T cells and monocytes/macrophages.6,34 Thus, we evaluated secretion of IL-10 from THP-1, a widely used human monocytic leukemia cell line, following treatment with recombinant Gal-1, or the nanoparticles (Fig. 5). Here, LGALS1 is linked to monocytic leukemia.