Furthermore, the retinal anatomical and functional toxicity are not affected after treatment.<h4>Conclusions</h4>eVLPs exhibit the potential as a safe and efficient delivery platform for Cas9 ribonucleoproteins, achieving precise Vegfa downregulation and significant reduction in choroidal neovascularization in a mouse model of wet age-related macular degeneration. The gene discussed is VEGFA; the disease is wet macular degeneration.