NFE2L2 and neoplasm: Significantly, prior research has demonstrated the crucial function of the NRF2/KEAP1 signaling pathway in carcinogenesis and the relationship between redox and metabolism in cancer (Hayes and Dinkova-Kostova 2014), providing additional evidence that Nrf2 acts as an oncogene to encourage tumor cell motility and invasion, potentially by boosting the tumor’s resistance to oxidative stress.