These findings seem to be context-specific, since pharmacological inhibition of MMP12 protected Apoe−/− deficient mice from AAA (Di Gregoli et al, 2024), while, paradoxically, Mmp12−/−/Apoe−/− mice were more susceptible to AAA and subsequent rupture (Salarian et al, 2023). Here, MMP12 is linked to triple-A syndrome.