MMP12 and triple-A syndrome: Firstly, we obtained evidence that the same genetic variant (rs17368814) that increases plasma MMP12 levels by acting on its protein-coding gene also increased the risk for AAA (Posterior probability shared genetic signal: 97.5%; Mendelian randomisation estimate: hazard ratio = 1.15; p value = 3.3 × 10−16; Fig. EV6), providing support that changes in plasma MMP12 precede AAA onset.