Future studies are warranted to further explore the clinical relevance of asymmetric cortical microstructural alterations and their prognostic implications, and the association of cortical microstructure with other neuroimaging and fluid biomarkers of neuronal injury (such as plasma neurofilament light [NfL]), gliosis (plasma glial fibrillary acidic protein [GFAP]), neuroinflammation, proteinopathy and synaptic damage [36–38], across different mutation types in genetic FTD, and in sporadic forms of FTD with diverse clinical phenotypes. The gene discussed is NEFL; the disease is frontotemporal dementia.