Our prior studies demonstrate a strong correlation between G3BP1 ADP-ribosylation and SG assembly: G3BP1 ADP-ribosylation increases under conditions when stress granules form, whereas this ADP-ribosylation reduces upon infection when the MAR-degrading nsP3 macrodomain inhibits SG assembly (Leung et al, 2011; Jayabalan et al, 2021). The gene discussed is G3BP1; the disease is infection.