AKT1 and lung cancer: VVD-699 also inhibited phosphorylated AKT in KRASGly12Ser A549 human lung cancer cells, and this inhibition was lost in A549 cells that were modified through Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology to express p110α-Cys242Ser (Fig. 2C).