Consistent with our previous analysis, both YAP and TAZ overexpression in our 0905 and TS603 IDHmut glioma cultures displayed significant enrichment of the HDACi Resistance Gene Set, and this was also observed for our parental cultures (Figure 6, E–G), further highlighting the importance of YAP and TAZ in activating genes involved in HDACi resistance. This evidence concerns the gene YAP1 and central nervous system cancer.