Indeed, analysis of the TCGA-GBMLGG dataset showed that both IDHmut-codeleted (oligodendrogliomas) and IDHmut-noncodeleted (astrocytomas) have higher WWTR1 and YAP1 DNA methylation (Supplemental Figure 6, C and D), and lower WWTR1 and YAP1 gene expression, compared with IDHwt GBM (Supplemental Figure 7, A and B). This evidence concerns the gene WWTR1 and astrocytoma (excluding glioblastoma).