IDH2 and intrahepatic cholangiocarcinoma: In contrast, publicly available gene expression datasets for CS (Supplemental Figure 8, A and B), ICC (Supplemental Figure 8, C and D), and AML (Supplemental Figure 2, B and C) show no substantial difference in WWTR1 or YAP1 mRNA according to IDH status, matching their lack of differential HDACi sensitivity (Figure 1, B and C, and Supplemental Figure 2A).