The lymphocyte adaptor protein (LNK encoded by SH2B3) is a negative regulator of JAK-STAT signaling through direct interactions with JAK2 and JAK3, but LNK has also been implicated as an adaptor protein mediating STAT3 signaling from IL-6/gp130 in GBM [25, 26]. This evidence concerns the gene SH2B3 and glioblastoma.