FGF5 (fibroblast growth factor 5) is a well-established hypertension susceptibility gene, with genetic variants linked to elevated SBP, DBP, and stroke.60,61 Our findings further support a potential causal link between increased plasma FGF5 levels, BP, and subsequent CHD and ischaemic stroke, aligning with previous MR studies and reinforcing observational evidence on FGF5 plasma levels. This evidence concerns the gene FGF5 and stroke disorder.