For example, in chronic myelomonocytic leukemia (CMML), we showed that hypomethylating agents or G9A/GLP H3K9me2 methyltransferase inhibitors (H3K9me2 being histone marks repressing the expression of retrotransposons) alone are not sufficient to trigger retrotransposon overexpression to a level that induces antiviral responses. This evidence concerns the gene EHMT2 and chronic myelomonocytic leukemia.