ENaC is subjected to a complex array of post-translational regulatory processes – including protease activation and CFTR inhibition, which has been studied in relation to cystic fibrosis (Mall, 2020; Matalon et al., 2015) – but there is little known of ENaC regulation in relation to ciliary motility in PCD (Wu et al., 2018). This evidence concerns the gene CFTR and cystic fibrosis.