BMI1 and cystic fibrosis: BMI1-transduced basal cells from the bronchial epithelium of cystic fibrosis donors (CFBE cells) display characteristic ion transport and fluid homeostasis defects in ALI culture and have been used to assess physiological correction with an epithelial sodium channel (ENaC)-targeted small-interfering RNA (siRNA) therapy (Tagalakis et al., 2018).