Organ-specific irAEs showed distinct predictors: hepatitis with younger age, hepatitis B virus (HBV) infection, hepatic malignancy, multisystem irAEs, and elevated IL-10; myocarditis with multisystem irAEs, systemic inflammation markers (white blood cell count, WBC; neutrophil-to-lymphocyte ratio, NLR; systemic immune-inflammation index, SII; systemic inflammation response index, SIRI), and cardiac function indicators (left ventricular ejection fraction, LVEF; QRS duration); thyroiditis with multisystem irAEs and reduced IL-6; while pneumonitis with elevated platelet count (PLT) and IL-6. This evidence concerns the gene IL6 and thyroid gland disorder.