Moreover, we demonstrate that a higher frequency of circulating CD4<sup>+</sup> and CD8<sup>+</sup> lymphocytes express either the ligand (AREG) or receptor (EGFR) ex vivo, in sepsis, and expression of CD4<sup>+</sup> lymphocyte EGFR was associated with several features of immunosuppression. This evidence concerns the gene CD8A and Sepsis.