Furthermore, a reduction in electrical connectivity, as evidenced by the loss of Cx43, the primary atrial gap junction protein, leads to desynchronized cardiac activation and contraction.24 Consequently, LIPUS could alleviate MI-induced atrial electrical remodelling through decreasing P wave and PR duration, prolonging AERP, and increasing Cx43 expression in the atrium. The gene discussed is GJA1; the disease is myocardial infarction.