Histologically, tumors from Plp1::CreERT2; BrafCA/+; Ptenlox/+ animals were indistinguishable from their Ptenlox/lox counterparts (Fig. 3C-H), including the extensive infiltration of non-traced (tdTomato− and/or Sox10−) stromal cells, which was markedly higher compared to melanoma samples (Fig. 3D, Fig. S1B). Here, PLP1 is linked to melanoma.