Further, a subset of individuals with NF1 wild-type MPNST (3-12% depending on the study) have been reported to harbor BRAF mutations, among which BRAFV600E is the most frequent, similar to observations in melanoma and additional epithelial cancers (Hirbe et al., 2014; Kao et al., 2022; Kaplan et al., 2018). This evidence concerns the gene BRAF and malignant peripheral nerve sheath tumor.