Wnt GOF was achieved using the Ctnnb1Ex3-lox allele, which allows Ctnnb1 exon 3 depletion and subsequent Ctnnb1 stabilization upon Cre recombination and promotes melanoma initiation in the same oncogenic setting (Damsky et al., 2011) (Fig. 6A). This evidence concerns the gene CTNNB1 and melanoma.