It is well established that developmental programs reminiscent of embryonic NC become reactivated in melanoma (Diener et al., 2021), and it is conceivable that this also occurs in our MPNST model, similar to processes described in MPNSTs driven by genetic loss of NF1 and PRC2 deficiency (Zhang et al., 2022). Here, NF1 is linked to malignant peripheral nerve sheath tumor.