Although BRAFV600E-mutated MPNSTs are rarely reported clinically, their true prevalence may be underestimated, as BRAF status is often used diagnostically to favor melanoma over MPNST, and some amelanotic melanomas, especially the spizoid subtype, are molecularly challenging to diagnose (Dimonitsas et al., 2018; Garrido-Ruiz et al., 2010). Here, BRAF is linked to malignant peripheral nerve sheath tumor.