EZH2 and neoplasm: Likewise, Tyr::CreERT2 - driven Ezh2 GOF, which results in canonical Wnt signal activation in the melanocyte lineage, promotes melanoma formation (Zingg et al., 2018), whereas Plp1::CreERT2 -driven Ezh2 GOF in MPNSTs had no overt effect on the tumor phenotype.