IFNG and periodontitis: 2023). In addition, the reduced levels of IFN‐γ may reflect a more destructive immune response and increased susceptibility to disease, a pattern previously observed in individuals with similar clinical characteristics (Monteiro et al. 2022). IFN‐γ plays a key role in infection control by promoting phagocytosis and inducing the production of inflammatory cytokines and molecules, and it has been suggested to exert a protective effect against the pathogenesis of periodontitis (Pan et al. 2019).