In summary, our findings demonstrate that CysLT<sub>1</sub>R activation inhibits hippocampal Na<sup>+</sup>/K<sup>+</sup>-ATPase activity in mice through a PKC-dependent mechanism, providing a potential molecular basis for LTD<sub>4</sub> involvement in the pathophysiology of various neurological disorders. Here, PRRT2 is linked to nervous system disorder.