Subgroup analyses revealed that differences in detection method, sample type, and geographic regions could influence measured cytokine levels.<h4>Conclusions</h4>The elevated IFN levels in SLE patients, with a significant correlation of IFNγ with disease activity, suggest their role in disease pathogenesis and potential as a biomarker for monitoring disease activity. The gene discussed is IFNA1; the disease is systemic lupus erythematosus.