Significantly elevated levels of IFNα (SMD = 1.428, 95%CI [0.78, 2.08], p < 0.001) and IFNγ (SMD = 0.922, 95%CI [0.32, 1.52], p = 0.003) in SLE patients compared with HCs were observed. This evidence concerns the gene IFNG and systemic lupus erythematosus.