One vesicle trafficking protein that is overexpressed in PAAD is myoferlin (Turtoi et al, 2011), a membrane protein physiologically involved in myoblast fusion and intracellular trafficking of membrane receptors such as IGF1R (Demonbreun et al, 2010; Doherty et al, 2005). This evidence concerns the gene PROS1 and pancreatic adenocarcinoma.