Of note, while depleting stromal myoferlin and impairing tumor desmoplasia alone could result in more aggressive tumors due to improved vascularization and promoted tumor cell dissemination (Rhim et al, 2014; Olive et al, 2009; Provenzano et al, 2012), we did not observe increased tumor burden upon stromal myoferlin depletion. Here, MYOF is linked to neoplasm.