Accordingly, ORA on cancer cell-specific DEGs showed a downregulation of mitochondria-related genes, in agreement with the described mitochondrial role of myoferlin in pancreatic cancer cells (Rademaker et al, 2018; Anania et al, 2024) (Fig. EV6), suggesting that a COPII-related function of myoferlin is only minor in cancer cells. This evidence concerns the gene MYOF and familial pancreatic carcinoma.