MAVS and viral infectious disease: Instead, NLRP3 senses cellular perturbations induced by viral infections, including the activation of the mitochondrial antiviral-signaling protein MAVS, RIPK1-RIPK3-DRP1 signaling, K+ efflux, ROS accumulation, lysosome and mitochondrial damage, and the release of oxidized DNA and the lysosomal protease cathepsin B [174–179].