While continuous Treg cell depletion led to flagrant splenomegaly and lymphadenopathy, these manifestations were unexpectedly mild following continuous Foxp3 degradation in Foxp3AIDR26TIR1(F74G) mice treated with 5-ph-IAA for the same duration (Fig. 1e). The gene discussed is FOXP3; the disease is Lymphadenopathy.