FOXP3 and autoimmune disease: This conclusion is supported by our findings that Foxp3 degradation induced upon 5-ph-IAA treatment of adult Foxp3AIDR26TIR1(F74G) mice for up to 4 weeks did not result in clinical manifestations of autoimmune disease or wasting, whereas Foxp3DTR mice of similar age subjected to DT-induced Treg cell ablation succumbed to the disease within 2–3 weeks.