scRNA-seq profiling of tumor-infiltrating Treg cells isolated from Foxp3AIDR26WT and Foxp3AIDR26TIR1(F74G) mice following 15 days of continuous Foxp3 degradation showed profound and widespread transcriptional alterations within tumor Treg cells visualized by UMAP (Fig. 7i). Here, FOXP3 is linked to neoplasm.