FOXP3 and hepatitis A virus infection: In this regard, hepatitis and liver damage, associated with a marked immune infiltration, elevated serum alanine aminotransferase and diminished albumin in Treg cell-depleted Foxp3DTR mice, were undetectable in Foxp3AIDR26TIR1(F74G) mice after 4 weeks of continuous Foxp3 degradation (Fig. 1i–k).