TRIM21 and infection: Notably, we also identified several fungal proteins previously localized to the extracellular vesicles of C. neoformans, including the HSP60-like protein, ATP synthase subunit alpha, phosphoglycerate kinase, peroxiredoxin, transcriptional regulator SSA1, and glyceraldehyde-3-phosphate dehydrogenase, suggesting the release of vesicles during infection and subsequent dissemination throughout the blood (69, 107).