A previous analysis of the EAST AFNET biosample study found that low concentrations of ANGPT2, BMP10, and NT-proBNP identify patients with AF who are likely to attain sinus rhythm during follow-up.8 Based on these findings, NT-proBNP concentrations were used to quantify Atrial cardiomyopathy in this study. Here, NPPB is linked to atrial fibrillation.