Furthermore, depletion of NSUN2 significantly enhances type I IFN responses against RSV, MPV, VSV, SeV, and HSV,38 while knockdown or knockout of NSUN2 enhances the expression of type I IFN and ISGs during viral infections with SARS-CoV, SeV, HSV-1, and ZIKV.44 The gene discussed is NSUN2; the disease is viral infectious disease.