NFKB1 and osteosarcoma: However, unresolved questions remain, such as the divergent regulation of NF-κB (activation in endothelium vs inhibition in osteosarcoma cells under high temperature), which may stem from cell-type-specific PTM crosstalk (Liu et al., 2015; Kardyńska et al., 2018), and the unclear relationship (mutually exclusive or cooperative) between HSP27 phosphorylation and SUMOylation.