NLRP3 and metabolic dysfunction-associated steatotic liver disease: Another study showed that bisphenol A (BPA) enhances OGT-mediated O-GlcNAcylation of NLRP3, leads to abnormal lipid accumulation, and induces pyroptosis in HepG2 cells, thus accelerating the progression of non-alcoholic fatty liver disease (NAFLD) in vitro (Zhang Y. et al., 2024).