The results indicated that the effects of Sukkari date extract were comparable to those of Amaryl (a known antidiabetic medication). Both treatments led to significant improvements in the measured parameters, suggesting that Sukkari date extract could be a viable alternative or complementary therapy for diabetes, as evidenced by the significant reduction in malondialdehyde (MDA) levels and an increase in superoxide dismutase (SOD) levels. This suggests that the extract may help mitigate oxidative stress associated with diabetes. This evidence concerns the gene SOD1 and diabetes mellitus.