Nevertheless, HITI would present an attractive personalized editing strategy for VWD patients harboring exon deletions on VWF, as it has been shown to achieve precise DNA knock--in in various genetic diseases including BCD patient-derived iPSCs and mice, a hemophilia B rat model, and primary CD34+ HSPCs (Bloomer et al., 2020; Chen X. et al., 2022; Meng et al., 2024). The gene discussed is VWF; the disease is von Willebrand disease (hereditary or acquired).