NFKB1 and neoplasm: Other regulatory pathways include the GNASAS1/miR-4319/NECAB3 axis, which modulates macrophage polarization to favor NSCLC progression (69), and the SR-A1/MAPK/IκB/NF-κB signaling cascade, where SR-A1 deficiency in TAMs leads to SAA1 upregulation, enhancing both macrophage migration and tumor invasion (70).