EIF4A3 and Sepsis: The dysregulation of the hsa_circ_0074158/EIF4A3 axis exacerbates sepsis-induced endothelial barrier dysfunction by destabilizing CTNNA1 mRNA, posing a critical medical challenge due to its complex pathophysiology.<h4>Conclusions</h4>This study provides new insights into the molecular mechanisms of sepsis and suggests potential therapeutic targets for its treatment.