TMVR-group showed more clinical sickness with more previous AMI (acute myocardial infarction) (P-value 0.023), with more coronary pathology (P-value 0.001), worse renal function (creatinine & EGFR, P-value 0.001), and worse lung capacity (COPD with P-value 0.001). The gene discussed is EGFR; the disease is acute myocardial infarction.