As for prognosis, memory deficits (11/30, 36.7%) were the most common residual symptom at follow-up, and early-onset patients were less likely to relapse (p = 0.038).<h4>Conclusions</h4>This study provides the first systematic characterization of early-onset LGI1-Ab encephalitis. This evidence concerns the gene LGI1 and viral encephalitis.