To ensure the physiological and pathological relevance of the CRISPR‐MI positive hits in AAA development, we further leveraged the scRNA‐Seq data of the mouse AAA model to refine the 2516 genes with false discovery rate (FDR)<0.05 in the aorta from CRISPR‐MI (Figure3A).[43] In the scRNA‐Seq dataset, monocytes/macrophages in mouse aorta could be classified into three subgroups: Ccr2+ M1‐like, Mrc1+ M2‐like, and Trem2+/Acp5+ (Figure 3B). This evidence concerns the gene TREM2 and triple-A syndrome.