TREM2 and atherosclerosis: In atherosclerosis, it has been shown that in early atherosclerotic plaques, the selective removal of macrophages via macrophage‐specific death could have plaque‐stabilizing effects and reduced plaque inflammation.[93] In the Trem2 KO mice, we did not observe decreased monocytes in the circulation, so we supposed that Trem2 might be disposable for monocyte differentiation and survival but critical for monocyte‐to‐macrophage maturation and mature macrophage survival.