We select positive genes in our screen that at least 2 out of 4 sgRNAs reach significance (FDR P value < 0.05).[68] The gene set enrichment analysis (GSEA) results of enriched gene sets in the aorta included unfolded protein response,[69] oxidative phosphorylation,[70] mTORC1 signaling,[71] and TNFα signaling via NF‐κB,[72] which are known to be implicated in monocyte infiltration or aortic aneurysm (Figure 2F). This evidence concerns the gene NFKB1 and aortic aneurysm.