The sTREM2 (Met1‐His157) was fused with a human IgG1 Fc fragment to increase its secretion and half‐life in circulation (Figure8A).[83] We established the AAA model by AngII infusion into Ldlr KO mice with the injection of AAV‐Fc or AAV‐sTREM2‐Fc (Figure 8B). Here, LDLR is linked to triple-A syndrome.