METTL14 and neoplasm: m6A methylation critically regulates RNA metabolism, including stability, splicing, translation, and localization, and is increasingly recognized as a key modulator of tumor angiogenesis.[8, 49] The METTL3/METTL14/WTAP methyltransferase complex deposits m6A marks, whereas FTO and ALKBH5 mediate demethylation, and various “reader” proteins such as YTHDF, IGF2BP, and HNRNP determine RNA fate.[21, 22] We show that METTL14 catalyzes m6A deposition in the 3′‐UTR of ADAM17 mRNA, generating binding sites for FMR1 that facilitate the recruitment of RNA decay machinery.