m6A methylation critically regulates RNA metabolism, including stability, splicing, translation, and localization, and is increasingly recognized as a key modulator of tumor angiogenesis.[8, 49] The METTL3/METTL14/WTAP methyltransferase complex deposits m6A marks, whereas FTO and ALKBH5 mediate demethylation, and various “reader” proteins such as YTHDF, IGF2BP, and HNRNP determine RNA fate.[21, 22] We show that METTL14 catalyzes m6A deposition in the 3′‐UTR of ADAM17 mRNA, generating binding sites for FMR1 that facilitate the recruitment of RNA decay machinery. This evidence concerns the gene WTAP and neoplasm.