ADAM17 and neoplasm: ADAM17 is traditionally recognized for its pro‐angiogenic activity via metalloproteinase‐dependent shedding of membrane‐bound substrates.[29, 30] Recent studies suggest that tumor‐derived exosomes can serve as alternative carriers of functional ADAM17 to modulate endothelial cell behavior.[39] Inhibition of exosome release from 786‐O and A498 cells using GW4869 (10 μm, 24 h) significantly reduced HUVEC tube formation, indicating a substantial role of exosomes in angiogenesis (Figure9A).