ADAM17 and nonpapillary renal cell carcinoma: When endothelial cells take up these exosomes, ADAM17 not only continues to cleave pro‐angiogenic ligands but also increases vascular permeability and induces leakage, thereby establishing a pre‐metastatic niche.[39] Collectively, ADAM17 exerts a dual role in ccRCC angiogenesis, it not only facilitates pro‐angiogenic factor release at the tumor cell surface but is also delivered to endothelial cells via exosomes, amplifying pro‐angiogenic signaling.