FMR1 and nonpapillary renal cell carcinoma: Collectively, these findings establish a novel mechanism whereby USP10 deubiquitinates FMR1 at K593 to maintain its stability, whereas circAHNAK destabilizes FMR1 by competitively disrupting USP10 binding, thereby modulating ADAM17 expression and enhancing angiogenesis in ccRCC.