Collectively, these findings establish a novel mechanism whereby USP10 deubiquitinates FMR1 at K593 to maintain its stability, whereas circAHNAK destabilizes FMR1 by competitively disrupting USP10 binding, thereby modulating ADAM17 expression and enhancing angiogenesis in ccRCC. The gene discussed is ADAM17; the disease is nonpapillary renal cell carcinoma.