Notably, POSTN expression demonstrated inverse correlations with key immune checkpoint regulators (ADORA2A, CD160, CD244; Figure 6G), while exhibiting positive associations with VEGFR2, a dual‐function mediator of both angiogenic signaling and metastasis‐associated immunosuppression.[39] To evaluate clinical implications, we applied ImmuCellAI algorithms to stratify TCGA‐HCC patients (N = 365) by predicted immunotherapy responsiveness. Here, CD244 is linked to hepatocellular carcinoma.