The pleiotropic factor SEMA3C maintains cancer stem cell populations while driving angiogenesis and invasive processes.[29] POSTN demonstrates dual signaling activation through integrin αvβ3‐mediated Akt/PKB survival pathways and Wnt/β‐catenin cascades that sustain tumor expansion.[30, 31] CXCL6, while canonically immunomodulatory, paradoxically accelerates neoplastic growth and metastatic dissemination in HCC.[32]. This evidence concerns the gene POSTN and hepatocellular carcinoma.