[38] Strikingly, POSTN expression (a key hmmyCAF marker) exhibited significant inverse correlations with TMB scores (Spearman's rho = ‐0.22, p = 2.04e‐05; Figure 6F), suggesting potential mechanistic links between hmmyCAF abundance and immunotherapy resistance in HCC. This evidence concerns the gene POSTN and hepatocellular carcinoma.