RESULTS: The findings show that heightened DEPDC1 expression correlates with significantly upregulated DEGs associated with critical signaling pathways, including Hedgehog, Hippo, MAPK, MYC, NF-KB, Notch, p27, p53, PI3K/AKT, PLK1, RbE2F, TGF-β, WNT, and MCM across numerous cancers. The gene discussed is NFKB1; the disease is cancer.