CD274 and Familial prostate cancer: Examples of translation include the EpiSwitch PSE test for prostate cancer, which achieved 94% accuracy and reduced unnecessary biopsies by 79% in prospective and real-world studies, and the CiRT test for immunotherapy response, which predicts PD-1/PD-L1 response with 85% accuracy, outperforming standard PD-L1 IHC [20, 22, 85].