The pathway map points to coordinated disturbance of cytokine signalling, innate immune sensing and downstream JAK/STAT transcriptional programmes — a pattern compatible with (i) peripheral immune activation, (ii) altered T-cell regulation (IL-2/IL-10 axis), and (iii) neuroimmune cross-talk that can produce fatigue, cognitive symptoms and autonomic dysfunction described in ME/CFS [44]. Here, IL10 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.