In addition, enrichments existed for other metabolic risk factors (Fig. 3b), including HDL-cholesterol (OR for adiponectin and leptin, respectively, 465.8 and 102.8, pfdr<0.001), triglycerides (ORs 1917.4 and 413.7, pfdr<0.001), systolic BP (ORs 215.2 and 137.4, pfdr<0.001), fasting insulin (ORs 435.5 and 147.5, pfdr<0.001) and glucose levels (ORs 121.4 and 22.0, pfdr<0.001), as well as type 2 diabetes itself (ORs 533.8 and 100.6, pfdr<0.001), highlighting the relevance of our CpGs to metabolic health as a whole. This evidence concerns the gene LEP and type 2 diabetes mellitus.