Additionally, three cases with traditional AML-defining gene fusions routinely evaluated by cytogenetic analysis, CBFB::MYH11 (SJ032253), RBM15::MRTFA (SJ030209), and KMT2A::MLLT10 (SJ030361), were only identified by iWGS-WTS (Table 1). The gene discussed is KMT2A; the disease is acute myeloid leukemia.