Indeed, iWGS-WTS identified AML-defining genetic alterations in seven of these nine cases (1 KMT2A::ELL, 1 RBM15::MRTFA, 1 NUP98::KDM5A, 1 NPM1 mutation, and biallelic alterations of TP53 in 3 cases), and revealed a CDK6::HOXA13 fusion and a TEC::MLLT10 (rarely reported in-frame fusion) in the remaining two cases (SJ030410 and SJ030773), respectively (Supplementary Table S8, B). Here, KDM5A is linked to acute myeloid leukemia.