STAT3 and cancer: Gene enrichment analysis (GSEA) using the hallmark signatures of cancer identified pathways related to cytokine signaling and inflammatory response over-expressed in EATLs (IL6_JAK_STAT3 and IL2_STAT5 signaling, IFN_alpha_response and INF_gamma_response, TNF_alpha signaling and Inflammatory_response pathway) (Fig. 4D).