CHSY1 and neoplasm: CHSY1 shows gene body hypermethylation (positively correlated with expression) in African tumours and correlates with poor prognosis in gastric cancer (Liu et al, 2021), while accumulation of its chondroitin sulfate chains is linked to prostate tumour aggressivity (Tóth et al, 2022), although no research has reported PCa gene-specific alterations.