Hypermethylated elements included target genes involved in tumour-suppressor binding motifs (FOXO4, SMAD2, TCF21, RB1, TP53), whereas target genes of hypomethylated elements belong to developmental pathways and oncoprotein binding motifs, including E12 (encoded by TCF3, a PCa oncogene). The gene discussed is FOXO4; the disease is neoplasm.