Notable DNA methylation differences in prostate tumours between ancestries include TIMP3 hypermethylation in Black over White Americans (Rubicz et al, 2019), while glaring inconsistencies include prostate tumour CD44 hypermethylation (Woodson et al, 2003) versus no differential methylation (Das et al, 2006), and PMEPA1 hypermethylated (Rubicz et al, 2019) versus hypomethylated (Sharad et al, 2014) for Black Americans. This evidence concerns the gene PMEPA1 and prostate neoplasm.