CHSY1 shows gene body hypermethylation (positively correlated with expression) in African tumours and correlates with poor prognosis in gastric cancer (Liu et al, 2021), while accumulation of its chondroitin sulfate chains is linked to prostate tumour aggressivity (Tóth et al, 2022), although no research has reported PCa gene-specific alterations. The gene discussed is CHSY1; the disease is posterior cortical atrophy.