Ancestry-associated enhancer targets included genes regulated by the ETS2 proto-oncogene and FOXO4 tumour suppressor, while tumour-associated hypermethylated promoter/enhancer elements corresponded to genes harbouring binding motifs for key tumour suppressors (FOXO4, SMAD2, TCF21, RB1, TP53). The gene discussed is RB1; the disease is neoplasm.