Hypermethylated in African tumours, NBEA has been shown to be downregulated in PCa (Schaeffer et al, 2008), CHL1 implicated in PCa predisposition (Rökman et al, 2005) and RNF217 has shown reduced copy number/expression in radioresistant LNCaP (Seifert et al, 2019). This evidence concerns the gene RNF217 and neoplasm.