Of the 405 CpGs found to be African-specifically differentially methylated in this study, 27 CpGs displayed a DMP/DMR |Δβ| ≥ 20%, annotated to 16 genes: GJB5, CD1E, C2orf88, SLC19A3, PROM1, ARL9, MIR575, SLC12A9, LRRC4, TACC1, HOXC4, ADCY4, PYCARD, CX3CL1, FBXO17 and KLF8. While 11 genes, including PYCARD, have PCa associations (Dataset EV29), it appears that GJB5, CD1E, SLC19A3, SLC12A9 and FBXO17 have not been previously reported in relation to PCa in published studies. This evidence concerns the gene KLF8 and posterior cortical atrophy.